Skip to Main content Skip to Navigation
Journal articles

Lymphovascular space invasion and Estrogen Receptor status in high-grade serous ovarian cancer-a multicenter study by the FRANCOGYN group

Abstract : BACKGROUND: The aim of this study was to evaluate the impact of Lymphovascular Space Invasion (LVSI) on Overall Survival (OS) and Recurrence-Free Survival (RFS) in patients managed for high-grade serous epithelial ovarian cancer (HGSOC). MATERIALS AND METHODS: Retrospective multicenter study by the FRANCOGYN research group between January 2001 and December 2018. All patients managed for HGSOC and for whom histological slides for the review of LVSI were available, were included. The characteristics of patients with LVSI (LVSI group) were compared to those without LVSI (No LVSI group). A Cox analysis for OS and RFS analysis was performed in all populations. RESULTS: Over the study period, 410 patients were included in the thirteen institutions. Among them, 289 patients had LVSI (33.9%). LVSI was an independent predictive factor for poorer Overall and Recurrence-Free Survival. LVSI affected OS (p<0.001) and RFS (p<0.001), Association of LVSI status and estrogen receptor status (ER) also affected OS and RFS (p=0.04; p=0.04 respectively). CONCLUSION: The presence of LVSI in HGSOC has an impact on OS and RFS and should be routinely included in the pathology examination along with ER status.
Complete list of metadata

https://hal.archives-ouvertes.fr/hal-03420228
Contributor : Laurent Jonchère Connect in order to contact the contributor
Submitted on : Wednesday, November 10, 2021 - 4:04:14 PM
Last modification on : Friday, May 20, 2022 - 11:06:35 AM
Long-term archiving on: : Friday, February 11, 2022 - 7:18:59 PM

Licence

Copyright

Identifiers

Citation

Jerome Lorenzini, Marion Deberti, Gilles Body, Xavier Carcopino, Cyril Touboul, et al.. Lymphovascular space invasion and Estrogen Receptor status in high-grade serous ovarian cancer-a multicenter study by the FRANCOGYN group. Journal of Gynecology Obstetrics and Human Reproduction, Elsevier, 2022, 51 (1), pp.102242. ⟨10.1016/j.jogoh.2021.102242⟩. ⟨hal-03420228⟩

Share

Metrics

Record views

179

Files downloads

0