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Successful treatment of Aspergillus fumigatus sternal osteomyelitis with isavuconazole in a heart transplant recipient

Abstract : A 65-year-old man was diagnosed with an invasive Aspergillus fumigatus infection with sternal osteomyelitis 4 months after heart transplantation. Unfortunately, after 8 weeks patient developed severe cutaneous and neurological toxicities induced by voriconazole leading to drug discontinuation. Therefore, isavuconazole was chosen as second-line therapy. The patient presented a favorable outcome and tolerance was excellent after ten months monotherapy. Here, we report for a first time, an successful isavuconazole-based treatment of sternal osteomyelitis aspergillosis in a cardiac recipient.
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https://hal.univ-lille.fr/hal-03324222
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Submitted on : Monday, August 23, 2021 - 1:41:33 PM
Last modification on : Wednesday, November 3, 2021 - 4:33:49 AM

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Ady Assaf, Emmanuel Faure, Kevin Sermet, Severine Loridant, Jordan Leroy, et al.. Successful treatment of Aspergillus fumigatus sternal osteomyelitis with isavuconazole in a heart transplant recipient. Transplant Infectious Disease, Wiley, 2020, 22 (5), pp.e13313. ⟨10.1111/tid.13313⟩. ⟨hal-03324222⟩

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