Challenges for cysteamine stabilization, quantification, and biological effects improvement

Carla Atallah (1, 2) , Catherine Charcosset (2) , Hélène Greige-Gerges (1)

1 LU / ULB - الجامعة اللبنانية [بيروت] = Lebanese University [Beirut] = Université libanaise [Beyrouth]
2 LAGEPP - Laboratoire d'automatique, de génie des procédés et de génie pharmaceutique

The aminothiol cysteamine, derived from coenzyme A degradation in mammalian cells, presents several biological applications. However, the bitter taste and sickening odor, chemical instability, hygroscopicity, and poor pharmacokinetic profile of cysteamine limit its efficacy. The use of encapsulation systems is a good methodology to overcome these undesirable properties and improve the pharmacokinetic behavior of cysteamine. Besides, the conjugation of cysteamine to the surface of nanoparticles is generally proposed to improve the intra-oral delivery of cyclodextrin-drug inclusion complexes, as well as to enhance the colorimetric detection of compounds by a gold nanoparticle aggregation method. On the other hand, the detection and quantification of cysteamine is a challenging mission due to the lack of a chromophore in its structure and its susceptibility to oxidation before or during the analysis. Derivatization agents are therefore applied for the quantification of this molecule. To our knowledge, the derivatization techniques and the encapsulation systems used for cysteamine delivery were not reviewed previously. Thus, this review aims to compile all the data on these methods as well as to provide an overview of the various biological applications of cysteamine focusing on its skin application.

Mots clés: Cysteamine; Detection; Encapsulation; Skin; Stability

Domaines: Pharmacie galénique

Carla Atallah, Catherine Charcosset, Hélène Greige-Gerges. Challenges for cysteamine stabilization, quantification, and biological effects improvement. Journal of Pharmaceutical Analysis, In press, ⟨10.1016/j.jpha.2020.03.007⟩. ⟨hal-03028849⟩