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Early phylodynamics analysis of the COVID-19 epidemic in France

Gonché Danesh 1 Baptiste Elie 1 Yannis Michalakis 1 Mircea T Sofonea 1 Antonin Bal 2, 3, 4, 5 Sylvie Behillil 6, 7 Grégory Destras 8, 9, 3, 4, 5 David Boutolleau 10, 11 Sonia Burrel 10, 11 Anne-Geneviève Marcelin 10, 11 Jean-Christophe Plantier 12 Vincent Thibault 13 Etienne Simon-Loriere 14 Sylvie van Der Werf 6, 7 Bruno Lina 6, 7 Laurence Josset 6, 7 Vincent Enouf 15, 6, 7 Samuel Alizon 16 
Résumé : France was one of the first countries to be reached by the COVID-19 pandemic. Here, we analyse 196 SARS-Cov-2 genomes collected between Jan 24 and Mar 24 2020, and perform a phylodynamics analysis. In particular, we analyse the doubling time, reproduction number (Rt) and infection duration associated with the epidemic wave that was detected in incidence data starting from Feb 27. Different models suggest a slowing down of the epidemic in Mar, which would be consistent with the implementation of the national lock-down on Mar 17. The inferred distributions for the effective infection duration and Rt are in line with those estimated from contact tracing data. Finally, based on the available sequence data, we estimate that the French epidemic wave originated between mid-Jan and early Feb. Overall, this analysis shows the potential to use sequence genomic data to inform public health decisions in an epidemic crisis context and calls for further analyses with denser sampling.
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Contributor : Samuel Alizon Connect in order to contact the contributor
Submitted on : Thursday, December 9, 2021 - 10:18:44 AM
Last modification on : Friday, August 5, 2022 - 12:03:12 PM


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Gonché Danesh, Baptiste Elie, Yannis Michalakis, Mircea T Sofonea, Antonin Bal, et al.. Early phylodynamics analysis of the COVID-19 epidemic in France. Peer Community Journal, Peer Community In/Centre Mersenne, 2021, 1, pp.e45. ⟨10.24072/pcjournal.40⟩. ⟨hal-03001114v2⟩



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