Deprotonative Functionalization of the Difluoromethyl Group
Résumé
The functionalization of 3-(difluoromethyl)pyridine has been developed via direct deprotonation of-CHF2 with a lithiated base and subsequent trapping with various electrophiles in THF. In situ quench gives access to 3-pyridyl-CF2-SiMe2Ph as a new silylated compound, which can be post-functionalized with a fluoride source to obtain a larger library of 3-(difluoroalkyl)pyridines that were not accessible via direct deprotonation.
Domaines
Chimie organique
Origine : Fichiers produits par l'(les) auteur(s)
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