Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation

Sylvain Garciaz (1) , Lia N’guyen Dasi (1) , Pascal Finetti (1) , Christine Chevalier (2, 1) , Julien Vernerey (1) , Mathilde Poplineau (1) , Nadine Platet (1) , Stéphane Audebert (3) , Matthieu Pophillat (4) , Luc Camoin (1) , François Bertucci (5) , Boris Calmels (1) , Christian Recher (6) , Daniel Birnbaum (1) , Christian Chabannon (1) , Norbert Vey (1) , Estelle Duprez (1)

1 CRCM - Centre de Recherche en Cancérologie de Marseille
2 Chromatine et Infection - Chromatin and Infection
3 IPC - Institut Paoli-Calmettes
4 CIML - Centre d'Immunologie de Marseille - Luminy
5 Service d'Oncologie Médicale
6 Service Hématologie - IUCT-Oncopole [CHU Toulouse]

Background: The epigenetic machinery is frequently altered in acute myeloid leukemia. Focusing on cytogenetically normal (CN) AML, we previously described an abnormal H3K27me3 enrichment covering 70 kb on the HIST1 cluster (6.p22) in CN-AML patient blasts. Here, we further investigate the molecular, functional, and prognosis significance of this epigenetic alteration named H3K27me3 HIST1 in NPM1-mutated (NPM1mut) CN-AML.

Domains: Molecular biology; Genomics [q-bio.GN]; Cancer

Sylvain Garciaz, Lia N’guyen Dasi, Pascal Finetti, Christine Chevalier, Julien Vernerey, et al.. Epigenetic down-regulation of the HIST1 locus predicts better prognosis in acute myeloid leukemia with NPM1 mutation. Clinical Epigenetics, 2019, 11 (1), ⟨10.1186/s13148-019-0738-6⟩. ⟨hal-02322283⟩