Synthesis and evaluation of non-hydrolyzable d-mannose 6-phosphate surrogates reveal 6-deoxy-6-dicarboxymethyl-d-mannose as a new strong inhibitor of phosphomannose isomerases

Johanna Foret; Benoit de Courcy; Nohad Gresh; Jean-Philip Piquemal; Laurent Salmon

Synthesis and evaluation of non-hydrolyzable d-mannose 6-phosphate surrogates reveal 6-deoxy-6-dicarboxymethyl-d-mannose as a new strong inhibitor of phosphomannose isomerases

Johanna Foret ¹ Benoit de Courcy ² Nohad Gresh ³ Jean-Philip Piquemal ² Laurent Salmon ¹

1 ICMO - ICMO

2 LCT - Laboratoire de chimie théorique

3 PMC - UMR_S 648 - Pharmacochimie Moléculaire et Cellulaire

Document type :

Journal articles

Domain :

Chemical Sciences

Chemical Sciences / Theoretical and/or physical chemistry

Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-02126828
Contributor : Jean-Philip Piquemal <>
Submitted on : Sunday, May 12, 2019 - 11:13:48 PM
Last modification on : Wednesday, May 15, 2019 - 11:12:09 AM

Synthesis and evaluation of non-hydrolyzable d-mannose 6-phosphate surrogates reveal 6-deoxy-6-dicarboxymethyl-d-mannose as a new strong inhibitor of phosphomannose isomerases

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Synthesis and evaluation of non-hydrolyzable d-mannose 6-phosphate surrogates reveal 6-deoxy-6-dicarboxymethyl-d-mannose as a new strong inhibitor of phosphomannose isomerases

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