Synthesis and evaluation of non-hydrolyzable d-mannose 6-phosphate surrogates reveal 6-deoxy-6-dicarboxymethyl-d-mannose as a new strong inhibitor of phosphomannose isomerases

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https://hal.archives-ouvertes.fr/hal-02126828
Contributor : Jean-Philip Piquemal <>
Submitted on : Sunday, May 12, 2019 - 11:13:48 PM
Last modification on : Wednesday, May 15, 2019 - 11:12:09 AM

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Johanna Foret, Benoit de Courcy, Nohad Gresh, Jean-Philip Piquemal, Laurent Salmon. Synthesis and evaluation of non-hydrolyzable d-mannose 6-phosphate surrogates reveal 6-deoxy-6-dicarboxymethyl-d-mannose as a new strong inhibitor of phosphomannose isomerases. Bioorganic & medicinal chemistry, Elsevier, 2009, 17 (20), pp.7100-7107. ⟨10.1016/j.bmc.2009.09.005⟩. ⟨hal-02126828⟩

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