CELL MIGRATION IN COMPLEX ENVIRONMENTS: CHEMOTAXIS AND TOPOGRAPHICAL OBSTACLES

Abstract : Cell migration is a complex phenomenon that plays an important role in many biological processes. Our aim here is to build and study models of reduced complexity to describe some aspects of cell motility in tissues. Precisely, we study the impact of some biochemical and mechanical cues on the cell dynamics in a 2D framework. For that purpose, we model the cell as an active particle with a velocity solution to a particular Stochastic Differential Equation that describes the intracellular dynamics as well as the presence of some biochemical cues. In the 1D case, an asymptotic analysis puts to light a transition between migration dominated by the cell's internal activity and migration dominated by an external signal. In a second step, we use the contact algorithm introduced in [16, 19] to describe the cell dynamics in a crowded environment. In the 2D case, we study how a cell submitted to a constant directional force that mimics the action of chemoattractant, behaves in the presence of obstacles. We numerically observe the existence of a velocity value that the cell can not exceed even if the directional force intensity increases. We find that this threshold value depends on the number of obstacles. Our result confirms a result that was already observed in a discrete framework in [4].
Document type :
Preprints, Working Papers, ...
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-02126709
Contributor : Christèle Etchegaray <>
Submitted on : Sunday, May 12, 2019 - 1:24:15 PM
Last modification on : Wednesday, May 15, 2019 - 4:50:43 AM

File

Cucchi_et_al.pdf
Files produced by the author(s)

Identifiers

  • HAL Id : hal-02126709, version 1

Citation

Alessandro Cucchi, Christèle Etchegaray, Nicolas Meunier, Laurent Navoret, Lamis Sabbagh. CELL MIGRATION IN COMPLEX ENVIRONMENTS: CHEMOTAXIS AND TOPOGRAPHICAL OBSTACLES. 2019. ⟨hal-02126709⟩

Share

Metrics

Record views

22

Files downloads

15