Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging

Hongguang Li (1) , Bethany Harriss (2) , Alkystis Phinikaridou (3) , Sara Lacerda (3) , Gregory Ramniceanu (4) , Bich-Thuy Doan (4) , Ka-Lok Ho (1) , Chi-Fai Chan (1, 5) , Wai-Sum Lo (5) , René Botnar (3) , Rongfeng Lan (1) , Cyrille Richard (4) , Ga-Lai Law (5) , Nicholas J. Long (2) , Ka-Leung Wong (1)

1 HKBU - Hong Kong Baptist University
2 Imperial College London
3 King‘s College London
4 UTCBS - UM 4 (UMR 8258 / U1022) - Unité de Technologies Chimiques et Biologiques pour la Santé
5 POLYU - The Hong Kong Polytechnic University [Hong Kong]

A novel dual-imaging cisplatin-carrying molecular cargo capable of performing simultaneous optical and MR imaging is reported herein. This long-lasting MRI contrast agent (r1 relaxivity of 23.4 mM-1s-1 at 3T, 25 oC) is a photo-activated cisplatin prodrug (PtGdL) which enables real-time monitoring of anti-cancer efficacy. PtGdL is a model for monitoring the drug delivery and anti-cancer efficacy by MRI with a much longer retention time (24 hours) in several organs such as renal cortex and spleen than GdDOTA and its motif control GdL. Upon complete release of cisplatin, all PtGdL is converted to GdL enabling subsequent MRI analyses of therapy efficacy within its reasonably short clearance time of 4 hours. There is also responsive fluorescence enhancement for monitoring by photon-excitation.

Keywords: multi-modal; cisplatin; fluorescence imaging; prodrug; drug delivery; MRI

Domains: Life Sciences [q-bio]

Hongguang Li, Bethany Harriss, Alkystis Phinikaridou, Sara Lacerda, Gregory Ramniceanu, et al.. Gadolinium and Platinum in Tandem: Real-time Multi-Modal Monitoring of Drug Delivery by MRI and Fluorescence Imaging. Nanotheranostics, 2017, 1 (2), pp.186-195. ⟨10.7150/ntno.18619⟩. ⟨hal-02079515⟩