Analysis of the Teashirt Target Genes in Ureteric Bud Development

Laurent Fasano (1) , Irene Sanchez-Martin (1) , Xavier Caubit (1)

1 IBDM - Institut de Biologie du Développement de Marseille

Microarrays and RNA-seq (RNA sequencing) are powerful techniques to assess transcript abundance in biological samples and to improve our understanding of the relationship between genotype and phenotype. Tshz3+/- heterozygous mouse is a model for a human 19q12 syndrome characterized by autistic traits and renal tract defects (Caubit et al., Nat Genet 48:1359-1369, 2016). To unravel renal tract pathological mechanisms, we took advantage of Tshz3 mouse and performed comparative genome-wide expression profiling on embryonic ureter and/or kidney.

Mots clés: Kidney; Microarray; Mouse; RNA-seq; Tshz3; Ureter

Domaines: Embryologie et organogenèse; Génomique, Transcriptomique et Protéomique [q-bio.GN]

Laurent Fasano, Irene Sanchez-Martin, Xavier Caubit. Analysis of the Teashirt Target Genes in Ureteric Bud Development. Seppo Vainio. Kidney Organogenesis Methods and Protocols, 1926, Springer, pp.223-232, 2019, Methods in Molecular Biology, 978-1-4939-9020-7. ⟨10.1007/978-1-4939-9021-4_18⟩. ⟨hal-02048084⟩