Na(+) channel function, regulation, structure, trafficking and sequestration
Résumé
This paper is the second of a series of three reviews published in this issue resulting from the University of California Davis Cardiovascular Symposium 2014: Systems approach to understanding cardiac excitation-contraction coupling and arrhythmias: Na(+) channel and Na(+) transport. The goal of the symposium was to bring together experts in the field to discuss points of consensus and controversy on the topic of sodium in the heart. The present review focuses on Na(+) channel function and regulation, Na(+) channel structure and function, and Na(+) channel trafficking, sequestration and complexing.
Mots clés
Abbreviations AP
action potential
CaM
calmodulin
CaMKII
CaM-dependent protein kinase II
Cx43
connexin43
EAD
early afterdepolarization
E m
membrane potential
I Na
Na + current
I NaL
the late Na + current
LQT3
long QT syndrome type 3
Na V channel
voltage-gated sodium channel
PD
pore-forming domain
VSD
voltage-sensing domain
Domaines
Sciences du Vivant [q-bio]
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...