Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

On the Natural History of Flavin-Based Electron Bifurcation

Abstract : Electron bifurcation is here described as a special case of the continuum of electron transfer reactions accessible to two-electron redox compounds with redox cooperativity. We argue that electron bifurcation is foremost an electrochemical phenomenon based on (a) strongly inverted redox potentials of the individual redox transitions, (b) a high endergonicity of the first redox transition, and (c) an escapement-type mechanism rendering completion of the first electron transfer contingent on occurrence of the second one. This mechanism is proposed to govern both the traditional quinone-based and the newly discovered flavin-based versions of electron bifurcation. Conserved and variable aspects of the spatial arrangement of electron transfer partners in flavoenzymes are assayed by comparing the presently available 3D structures. A wide sample of flavoenzymes is analyzed with respect to conserved structural modules and three major structural groups are identified which serve as basic frames for the evolutionary construction of a plethora of flavin-containing redox enzymes. We argue that flavin-based and other types of electron bifurcation are of primordial importance to free energy conversion, the quintessential foundation of life, and discuss a plausible evolutionary ancestry of the mechanism.
Document type :
Journal articles
Complete list of metadata

Cited literature [95 references]  Display  Hide  Download

https://hal-amu.archives-ouvertes.fr/hal-01828959
Contributor : LAURE AZZOPARDI Connect in order to contact the contributor
Submitted on : Thursday, July 5, 2018 - 5:38:18 PM
Last modification on : Wednesday, November 3, 2021 - 5:51:55 AM
Long-term archiving on: : Monday, October 1, 2018 - 6:45:45 PM

File

fmicb-09-01357 2018.pdf
Publication funded by an institution

Identifiers

Collections

Citation

Frauke Baymann, Barbara Schoepp-Cothenet, Simon Duval, Marianne Guiral, Myriam Brugna, et al.. On the Natural History of Flavin-Based Electron Bifurcation. Frontiers in Microbiology, Frontiers Media, 2018, 9, pp.1357 - 1357. ⟨10.3389/fmicb.2018.01357⟩. ⟨hal-01828959⟩

Share

Metrics

Record views

68

Files downloads

153