Characterization of the surface physico-chemistry of plasticized PVC used in blood bag and infusion tubing

H. Al Salloum (1, 2) , J. Saunier (1, 2) , Alexandre Dazzi (3, 4, 2) , Jackie Vigneron (5, 6, 2) , Arnaud Etcheberry (5, 6, 2) , Christian Marlière (7, 8, 2) , C. Aymes-Chodur (1, 2) , Jean-Marie Herry (9, 2) , M. Bernard (1, 2) , E. Jubeli (1, 2) , N. Yagoubi (1, 2)

1 UFR de Pharmacie - IFR 141 - EA 401
2 Université Paris-Saclay
3 LCPO - Laboratoire de Chimie Physique D'Orsay
4 CNRS - Centre National de la Recherche Scientifique
5 ILV - Institut Lavoisier de Versailles
6 UVSQ - Université de Versailles Saint-Quentin-en-Yvelines
7 ISMO - Institut des Sciences Moléculaires d'Orsay
8 UP11 - Université Paris-Sud - Paris 11
9 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé

Commercial infusion tubing and blood storage devices (tubing, blood and platelets bags) made of plasticized PVC were analyzed by spectroscopic, chromatographic and microscopic techniques in order to identify and quantify the additives added to the polymer (lubricants, thermal stabilizers, plasticizers) and to put into evidence their blooming onto the surface of the devices. For all the samples, deposits were observed on the surface but with different kinds of morphologies. Ethylene bis amide lubricant and metallic stearate stabilizers were implicated in the formation of these layers. In contact with aqueous media, these insoluble deposits were damaged, suggesting a possible particulate contamination of the infused solutions.

Mots clés: PVC; blood bag; infusion; lubricant; metallic stearate; blooming; Particulate contamination

Domaines: Sciences du Vivant [q-bio]

H. Al Salloum, J. Saunier, Alexandre Dazzi, Jackie Vigneron, Arnaud Etcheberry, et al.. Characterization of the surface physico-chemistry of plasticized PVC used in blood bag and infusion tubing. Materials Science and Engineering: C, 2017, 75, pp.317-334. ⟨10.1016/j.msec.2017.02.057⟩. ⟨hal-01595067⟩