Polyisobutylcyanoacrylate nanoparticles as drug carriers: influence of sulfur dioxide on the physico-chemical characteristics of ciprofloxacin- and doxorubicin-loaded nanoparticles
Résumé
The amount of sulfur dioxide present in isobutylcyanoacrylate monomer was examined for the entrapment of ciprofloxacin and doxorubicin into poly(isobutylcyanoacrylate) nanoparticles obtained by emulsion polymerization. In fact, SO 2 , commonly used as a polymerization inhibitor, was shown to be a crucial factor modulating the polymerization process. In this report, its optimal concentration to have reproducible preparations regarding size and highest association extent was about 0.5% for both drugs.