Abducing Biological Regulatory Networks from Process Hitting models

Abstract : The Process Hitting (PH) is a recently introduced framework to model concurrent processes. It is notably suitable to model Biological Regulatory Networks (BRNs) with partial knowledge of cooperations by defining the most permissive dynamics. On the other hand, the qualitative modeling of BRNs has been widely addressed using René Thomas' formalism. Given a PH model of a BRN, we first tackle the inference of the underlying Interaction Graph between components. Then the inference of corresponding Thomas' models is provided by inferring some parameters and abducing the compatible parametrizations.
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Maxime Folschette, Loïc Paulevé, Katsumi Inoue, Morgan Magnin, Olivier Roux. Abducing Biological Regulatory Networks from Process Hitting models. ECML-PKDD 2012 Workshop on Learning and Discovery in Symbolic Systems Biology, Sep 2012, Bristol, United Kingdom. ⟨hal-01314470⟩

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