A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication

Marie Dujardin (1, 2) , Vanesa Madan (3) , Roland Montserret (4) , Puneet Ahuja (2, 1) , Isabelle Huvent (2, 1) , Helene Launay (2, 1) , Arnaud Leroy (5, 2, 1) , Ralf Bartenschlager (3) , François Penin (4) , Guy Lippens (2, 1) , Xavier Hanoulle (2, 1)

1 Université de Lille
2 UGSF - Unité de Glycobiologie Structurale et Fonctionnelle - UMR 8576
3 Universität Heidelberg [Heidelberg] = Heidelberg University
4 IBCP - Institut de biologie et chimie des protéines [Lyon]
5 UP11 - Université Paris-Sud - Paris 11

Domaines: Biochimie, Biologie Moléculaire; Biologie structurale [q-bio.BM]; Biophysique

Marie Dujardin, Vanesa Madan, Roland Montserret, Puneet Ahuja, Isabelle Huvent, et al.. A Proline-Tryptophan Turn in the Intrinsically Disordered Domain 2 of NS5A Protein Is Essential for Hepatitis C Virus RNA Replication. Journal of Biological Chemistry, 2015, 290 (31), ⟨10.1074/jbc.M115.644419⟩. ⟨hal-01221930⟩