A model for gene deregulation detection using expression data

Abstract : In tumoral cells, gene regulation mechanisms are severely altered, and these modifications in the regulations may be characteristic of different subtypes of cancer. However, these alterations do not necessarily induce differential expressions between the subtypes. To answer this question, we propose a statistical methodology to identify the misregulated genes given a reference network and gene expression data. Our model is based on a regulatory process in which all genes are allowed to be deregulated. We derive an EM algorithm where the hidden variables correspond to the status (under/over/normally expressed) of the genes and where the E-step is solved thanks to a message passing algorithm. Our procedure provides posterior probabilities of deregulation in a given sample for each gene. We assess the performance of our method by numerical experiments on simulations and on a bladder cancer data set.
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BMC Systems Biology, BioMed Central, 2015, <10.1186/1752-0509-9-S6-S6>
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https://hal.archives-ouvertes.fr/hal-01154154
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Soumis le : vendredi 8 janvier 2016 - 16:04:24
Dernière modification le : samedi 18 février 2017 - 01:19:46

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Thomas Picchetti, Julien Chiquet, Mohamed Elati, Pierre Neuvial, Rémy Nicolle, et al.. A model for gene deregulation detection using expression data. BMC Systems Biology, BioMed Central, 2015, <10.1186/1752-0509-9-S6-S6>. <hal-01154154v2>

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