Analysis of the HIV Eradication Phenomenon at the Early Stage of Infection with an Extracellular Deterministic Model

H.J. Chang (1) , Claude Moog (2) , Alessandro Astolfi (3)

1 School of Electrical Engineering [Korea University]
2 IRCCyN - Institut de Recherche en Communications et en Cybernétique de Nantes
3 EEE Department

We investigate the phenomenon of HIV eradication at the early stage of the infection and evaluate the chance of the eradication with a mathematical model. We employ an extracellular deterministic model of the HIV infection dynamics and modify the model to include the pharmacokinetics and pharmacodynamics of antiretroviral HIV drugs. In addition we consider clinical experiments for the prevention of HIV infection using pre-exposure chemoprophylaxis treatment. Exploiting the mathematical model we implement the experiment numerically. The study in this paper is supported by the clinical results and provides a theoretical explanation for the results. The result suggests that the protocol of the experiment eradicates the virus in HIV infected patients.

Domaines: Automatique

H.J. Chang, Claude Moog, Alessandro Astolfi. Analysis of the HIV Eradication Phenomenon at the Early Stage of Infection with an Extracellular Deterministic Model. 36th Annual International IEEE EMBS Conference, Aug 2014, Chicago, United States. ⟨hal-01026198⟩