Ruthenium-catalyzed redox isomerization of trifluoromethylated allylic alcohols: mechanistic evidence for an enantiospecific pathway.
Résumé
Transfer news : A synthetic approach to chiral β‐CF3‐substituted saturated carbonyl compounds has been developed in which ruthenium complexes efficiently catalyze the redox isomerization of CF3‐bearing allylic alcohols by an intramolecular suprafacial enantiospecific 1,3‐hydrogen transfer (see scheme). This method was used for the enantioselective synthesis of (S )‐CF3‐citronellol.