Hybrid polymer/lipid vesicles: state of the art and future perspectives

Jean-François Le Meins (1, 2) , Christophe Schatz (1, 2) , Sébastien Lecommandoux (1, 2) , Olivier Sandre (1, 2)

1 LCPO - Laboratoire de Chimie des polymères organiques
2 Team 3 LCPO : Polymer Self-Assembly & Life Sciences

Hybrid vesicles resulting from the combined self-assembly of both amphiphilic copolymers and lipids have attracted particular interest from chemists and (bio)physicists over the last five years. Such assemblies may be viewed as an advanced vesicular structure compared to their liposome and polymersome forerunners as the best characteristics from the two different systems can be integrated in a new, single vesicle. To afford such a design, the different parameters controlling both self-assembly and membrane structure must be tuned. This highlight aims to present a comprehensive overview of the fundamental aspects related to these structures, and discuss emerging developments and future applications in this field of research.

Mots clés: STABILITY; MORPHOLOGY; ORGANIZATION; LIPID-MEMBRANES; BLOCK-COPOLYMERS; LINE TENSION; NANODOMAINS; LIPID RAFTS; POLYMERSOMES; AMPHIPOLS

Domaines: Polymères

Jean-François Le Meins, Christophe Schatz, Sébastien Lecommandoux, Olivier Sandre. Hybrid polymer/lipid vesicles: state of the art and future perspectives. Materials Today, 2013, 16 (10), pp.397-402. ⟨10.1016/j.mattod.2013.09.002⟩. ⟨hal-00926560⟩