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Genomic variation in seven Khoe-San groups reveals adaptation and complex African history.

Abstract : The history of click-speaking Khoe-San, and African populations in general, remains poorly understood. We genotyped ~2.3 million single-nucleotide polymorphisms in 220 southern Africans and found that the Khoe-San diverged from other populations ≥100,000 years ago, but population structure within the Khoe-San dated back to about 35,000 years ago. Genetic variation in various sub-Saharan populations did not localize the origin of modern humans to a single geographic region within Africa; instead, it indicated a history of admixture and stratification. We found evidence of adaptation targeting muscle function and immune response; potential adaptive introgression of protection from ultraviolet light; and selection predating modern human diversification, involving skeletal and neurological development. These new findings illustrate the importance of African genomic diversity in understanding human evolutionary history.
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https://hal.archives-ouvertes.fr/hal-00775886
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Submitted on : Monday, January 14, 2013 - 4:32:53 PM
Last modification on : Wednesday, June 2, 2021 - 3:48:01 PM

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Carina M Schlebusch, Pontus Skoglund, Per Sjödin, Lucie M Gattepaille, Dena Hernandez, et al.. Genomic variation in seven Khoe-San groups reveals adaptation and complex African history.. Science, American Association for the Advancement of Science, 2012, 338 (6105), pp.374-9. ⟨10.1126/science.1227721⟩. ⟨hal-00775886⟩

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