TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core.
Résumé
TNPO3 is a nuclear importer required for HIV-1 infection. Here, we show that depletion of TNPO3 leads to an HIV-1 block after nuclear import but prior to integration. To investigate the mechanistic requirement of TNPO3 in HIV-1 infection, we tested the binding of TNPO3 to the HIV-1 core and found that TNPO3 binds to the HIV-1 core. Overall, this work suggests that TNPO3 interacts with the incoming HIV-1 core in the cytoplasm to assist a process that is important for HIV-1 infection after nuclear import.
Domaines
Virologie
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...