Toward non-linear endomicroscopy for exploration of the pulmonary airways : preliminary spectroscopic study of human lung tissue using monomode fiber

Abstract : We are developing a non-linear fibered endomicroscope for imaging the extracellular matrix collagen and elastin fibrillar networks during bronchoscopy. As a proof of concept, laser pulses at the output of a standard 2 meter long single-mode fibre have been obtained with pulse duration of about 50 fs and pulse energy up to 50 uJ, using a specially designed grism line for the dispersion compensation. With these pulses, we performed a spectroscopic characterization of the non-linear endogenous signal, consisting of two-photon fluorescence and second harmonic generation, and originated from human pulmonary tissue of various thickness, both in forward and backward geometry of signal collection, with excitation at 830 nm.
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Conference papers
Endoscopic Microscopy VI, Nonlinear Endomicroscopy, Jan 2011, San franscisco - Californie, United States. 7893, pp.n°789309, <10.1117/12.875440>


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Submitted on : Tuesday, April 17, 2012 - 11:37:23 AM
Last modification on : Thursday, January 29, 2015 - 9:26:42 AM

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Donald Peyrot, Darine Abi Haidar, Claire Lefort, Nicolas Sandeau, Tigran Mansuryan, et al.. Toward non-linear endomicroscopy for exploration of the pulmonary airways : preliminary spectroscopic study of human lung tissue using monomode fiber. Endoscopic Microscopy VI, Nonlinear Endomicroscopy, Jan 2011, San franscisco - Californie, United States. 7893, pp.n°789309, <10.1117/12.875440>. <hal-00688280>

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