Promising immunomodulatory effects of selected strains of dairy propionibacteria as evidenced in vitro and in vivo.

Benoît Foligné (1, 2, 3) , Stéphanie-Marie Deutsch (4, 5) , Jérôme Breton (1, 2, 3) , Fabien J. Cousin (4, 5) , Joëlle Dewulf (1, 2, 3) , Michel Samson (6) , Bruno Pot (1, 2, 3) , Gwénaël Jan (4, 5)

1 Interactions cellulaires et moléculaires des bactéries pathogènes avec l'hôte
2 Laboratoire de Bactéries Lactiques et Immunité des Muqueuses
3 CIIL - Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204
4 STLO - Science et Technologie du Lait et de l'Oeuf
5 Unité mixte de recherche science et technologie du lait et de l'oeuf
6 SeRAIC - Signalisation et Réponses aux Agents Infectieux et Chimiques

Immunomodulatory properties of 10 dairy propionibacteria, analyzed on human peripheral blood mononuclear cells (PBMCs), revealed a highly strain-dependent induction of anti-inflammatory cytokine interleukin 10 (IL-10). Two selected strains of Propionibacterium freudenreichii showed a protective effect against two models of colitis in mice, suggesting a probiotic potential predicted by immune-based selection criteria for these cheese starter bacteria.

Domains: Microbiology and Parasitology

Benoît Foligné, Stéphanie-Marie Deutsch, Jérôme Breton, Fabien J. Cousin, Joëlle Dewulf, et al.. Promising immunomodulatory effects of selected strains of dairy propionibacteria as evidenced in vitro and in vivo.. Applied and Environmental Microbiology, 2010, 76 (24), pp.8259-64. ⟨10.1128/AEM.01976-10⟩. ⟨hal-00684731⟩