Detection of small variations in shape between two chromatographic peaks
Résumé
The detection of an impurity in a visually single peak by means of the “Distribution Function Method” necessitates a thorough control of every parameter which influences the shape of a peak. In particular, the heights of the peaks compared must be as equal as possible when the chromatographic response is not a linear function of the injected concentration. The Distribution Function Method can also be used for the determination of the region in which the chromatographic response is linear.