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Molecular and Clinical Characterization of Rotavirus From Diarrheal Infants Admitted to Pediatric Emergency Units in France.

Abstract : BACKGROUND:: Rotaviruses are the major cause of acute gastroenteritis in young children worldwide, and require careful surveillance, especially in the context of vaccination programs. Prospective surveillance is required to monitor and characterize rotavirus infections, including viral and clinical data, and to detect the emergence of potentially epidemic strains. METHODS:: Between 2006 and 2009, stool samples and clinical records were collected from 2044 children with acute diarrhea admitted to the pediatric emergency units of 13 French university hospitals. Rotaviruses were detected in stools, then genotyped by reverse transcription-polymerase chain reaction with regard to their outer capsid proteins VP4 and VP7. RESULTS:: The genotyping of 1947 rotaviruses showed that G1 (61.7%) and G9 (27.4%) strains were predominant and stable, followed by G2 (6.5%), G3 (4.0%), and G4 (2.5%) strains. Most strains were associated with P[8] (92.9%). Overall, 31 uncommon strains and possible zoonotic reassortants were detected including G12 and G8 strains, some being closely related to bovine strains. No difference in clinical presentation and severity was found among genotypes. CONCLUSIONS:: The relative stability of rotavirus genotypes currently cocirculating in France may ensure vaccine effectiveness in the short and medium term. However, the likely emergence of G12 and G8 strains should be monitored during ongoing and future vaccination programs, especially as all genotypes can cause severe infections. Special attention should be paid to the emergence of new rotavirus reassortants not included in current rotavirus vaccines.
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https://hal.archives-ouvertes.fr/hal-00510677
Contributor : Murielle Humbert <>
Submitted on : Friday, August 20, 2010 - 11:54:06 AM
Last modification on : Sunday, October 25, 2020 - 7:06:27 AM

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Alexis de Rougemont, Jérôme Kaplon, Sylvie Pillet, Olivier Mory, Arnaud Gagneur, et al.. Molecular and Clinical Characterization of Rotavirus From Diarrheal Infants Admitted to Pediatric Emergency Units in France.. Pediatr Infect Dis J, 2010, epub ahead of print. ⟨10.1097/INF.0b013e3181ef034e⟩. ⟨hal-00510677⟩

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