RESINFIT - UMR-S 1092
Antimicrobials: molecular supports of resistances and therapeutic innovations

This team works along lines relating to the molecular mechanisms involved in resistance to antimicrobial, antibiotic and antiviral drugs. The work has focussed on studying the diversity of resistant bacterial and viral strains, in order to get a better understanding of the developing of the acquisition of resistance within the microbial genomes and the kinetics of the emergence of resistance. The team has both fundamental and applied objectives.

The research subject can be broken down into two sectors:

  • The role of integrons in the multiple resistance of bacteria to antibiotics, Head : M-C Ploy
    Integrons are genetic elements which make up a natural system of antibiotic resistant gene expression and capture. The fundamental line of research consists of studying the regulation of the expression of resistance genes and the systems which allow them to be disseminated. The most applied line of research studies the possibility of developing strategies to help prevent bacteria from recruiting resistance genes.
  • The role of integrons in the multiple resistance of bacteria to antibiotics, Head : S. Alain
  • This subject includes the study of the mutations of phosphotransferase UL97 and DNA polymerase UL54 involved in resistance to antiviral drugs. The fundamental line of research studies the polymorphism of the mutation of resistant viral strains and explores the structure-activity relationship of proteins of the CMV termination complex. The most applied line of research consists of developing rapid tests to detect mutations which have led to relationships with companies and to the identification of new targets for the development of future antiviral drugs.

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