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The Shape of the Polymerization Rate in the Prion Equation

Abstract : We consider a polymerization (fragmentation) model with size-dependent parameters involved in prion proliferation. Using power laws for the different rates of this model, we recover the shape of the polymerization rate using experimental data. The technique used is inspired from an article of Zampieri et al. where the fragmentation dependency on prion strains is investigated. Our improvement is to use power laws for the rates whereas Zampieri et al. used a constant polymerization coefficient and linear fragmentation.
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Submitted on : Thursday, February 21, 2013 - 5:20:06 PM
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Pierre Gabriel. The Shape of the Polymerization Rate in the Prion Equation. Mathematical and Computer Modelling, Elsevier, 2011, Mathematical Methods and Modelling of Biophysical Phenomena, 53 (7-8), pp.1451-1456. ⟨10.1016/j.mcm.2010.03.032⟩. ⟨hal-00455390v2⟩



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