Detection in near-field domain of biomolecules adsorbed on a single metallic nanoparticle

Grégory Barbillon (1) , Jean-Louis Bijeon (1) , Jean-Sébastien Bouillard (1) , Jerome Plain (1) , Marc Lamy de La Chapelle (2, 1) , Pierre-Michel Adam (1) , Pascal Royer (1)

1 LNIO - Laboratoire de Nanotechnologie et d'Instrumentation Optique
2 CSPBAT - Chimie, Structures et Propriétés de Biomatériaux et d'Agents Thérapeutiques

In this paper, we study the performances of nanosensors based on Localized Surface Plasmon Resonance in the context of biological sensing. We demonstrate the sensitivity and the selectivity of our designed nanosensors by studying the influence of the concentration of Streptavidin on the shift of Localized Surface Plasmon Resonance wavelength. In addition, to study the detection of biomolecules on a single Au nanoparticle, we used a Scanning Near-field Optical Microscope. These results represent new steps for applications in biological research and medical diagnostics.

Mots clés: nanosensor; SNOM; streptavidin; Localized Surface Plasmon Resonance

Domaines: Optique / photonique

Grégory Barbillon, Jean-Louis Bijeon, Jean-Sébastien Bouillard, Jerome Plain, Marc Lamy de La Chapelle, et al.. Detection in near-field domain of biomolecules adsorbed on a single metallic nanoparticle. JOURNAL OF MICROSCOPY-OXFORD, 2008, 229 (2), pp.270-274. ⟨10.1111/j.1365-2818.2008.01898.x⟩. ⟨hal-00416065⟩