Toward a computer-aided methodology for topology-based simulation of the Golgi apparatus

Abstract : The Golgi apparatus is the place in the cell where proteins re main for a maturation phase before their excretion. Several hypotheses on its dynamics have been formulated under the form of schematic models. The GolgiTop working group initiated by the Epigenomics Project (Genopole, Evry) aims at studying the 3-dimensional structure and dynamics of the Golgi apparatus by building 3D structures with the help of computer graphics tools and by animating them using transformation rules which depend on topological, geometric and/or biochemical data. Finally, we introduce a first proposition for a computer-aided methodology for helping biologists to understand and choose hypotheses about the topology and dynamics of the Golgi apparatus.
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Chapitre d'ouvrage
Proc. of the Lille Spring school on Modelling and simulation of biological processes in the context of genomics, EDP SCIENCES, pp.89--104, 2008
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https://hal.archives-ouvertes.fr/hal-00353755
Contributeur : Agnès Arnould <>
Soumis le : vendredi 16 janvier 2009 - 12:51:35
Dernière modification le : jeudi 9 février 2017 - 15:59:36

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  • HAL Id : hal-00353755, version 1

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Mathieu Poudret, Jean-Paul Comet, Pascale Le Gall, François Képès, Agnès Arnould, et al.. Toward a computer-aided methodology for topology-based simulation of the Golgi apparatus. Proc. of the Lille Spring school on Modelling and simulation of biological processes in the context of genomics, EDP SCIENCES, pp.89--104, 2008. <hal-00353755>

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