The renal physiome project

S. Randall Thomas (1) , Fariza Tahi (1) , Peter Harris (2) , Andrew Lonie (2)

1 IBISC - Informatique, Biologie Intégrative et Systèmes Complexes
2 CCSE - Department of Computer Science and Software Engineering

We discuss current progress towards two complementary web resources being developed for the Renal Physiome: (1) a database (QKDB) for quantitative and anatomical data at all levels of kidney organization, including molecular-level information on membrane channels and transporters, structural and functional parameter values at the epithelial level, measured flows and concentrations along vessels and nephron segments, anatomical data (including imaging studies) at all scales, etc.; and (2) an interactive interface to mathematical models of kidney structure and function, built around a zoomable 3D virtual unilobed kidney. These resources will facilitate interaction among renal modelers, experimental laboratories, and clinical researchers.

Domaines: Informatique; Bio-informatique [q-bio.QM]; Bio-Informatique, Biologie Systémique [q-bio.QM]; Informatique et théorie des jeux [cs.GT]; Modélisation et simulation; Physiologie [q-bio.TO]; Urologie et Néphrologie; Interactions cellulaires [q-bio.CB]

S. Randall Thomas, Fariza Tahi, Peter Harris, Andrew Lonie. The renal physiome project. 3rd IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 2006, Arlington, United States. pp.820--823, ⟨10.1109/ISBI.2006.1625044⟩. ⟨hal-00339799⟩