Impact of cortical input on subthalamic activity during deep brain stimulation

Julien Modolo (1) , Anne Beuter (1)

1 IMS - Laboratoire de l'intégration, du matériau au système

Cortical afferences (e.g., primary motor cortex M1, and supplementary motor area SMA) are believed to play a role in the generation of abnormal oscillatory activity in the subthalamic nucleus (STN) in Parkinson's disease (PD). Using a computational model, we investigate how cortical inputs impact STN activity during deep brain stimulation (DBS). When cortical input to the STN is constant, high-frequency DBS is able to suppress pathological, low-frequency STN oscillations. On the contrary, when cortical input to the STN is oscillatory, DBS capacity to suppress STN abnormal oscillations is compromised. We propose that DBS induces a functional decoupling between cortex and STN. This functional decoupling may originate from spike cancellation following antidromic activation of cortical afferences.

Keywords: Statistical models; Neuronal models; Cognitive Science

Domains: Neurons and Cognition [q-bio.NC]; Neuroscience

Julien Modolo, Anne Beuter. Impact of cortical input on subthalamic activity during deep brain stimulation. Deuxième conférence française de Neurosciences Computationnelles, "Neurocomp08", Oct 2008, Marseille, France. ⟨hal-00331574⟩