Cell and plastid division are coordinated through the prereplication factor AtCDT1.

Cécile Raynaud (1) , Claudette Perennes (1) , Christophe Reuzeau (2) , Olivier Catrice (3) , Spencer Brown (3) , Catherine Bergounioux (1)

1 IBP - Institut de biotechnologie des plantes
2 Crop Design NV
3 ISV - Institut des sciences du végétal

The cell division cycle involves nuclear and cytoplasmic events, namely organelle multiplication and distribution between the daughter cells. Until now, plastid and plant cell division have been considered as independent processes because they can be uncoupled. Here, down-regulation of AtCDT1a and AtCDT1b, members of the prereplication complex, is shown to alter both nuclear DNA replication and plastid division in Arabidopsis thaliana. These data constitute molecular evidence for relationships between the cell-cycle and plastid division. Moreover, the severe developmental defects observed in AtCDT1-RNA interference (RNAi) plants underline the importance of coordinated cell and organelle division for plant growth and morphogenesis

Domains: Other [q-bio.OT]

Cécile Raynaud, Claudette Perennes, Christophe Reuzeau, Olivier Catrice, Spencer Brown, et al.. Cell and plastid division are coordinated through the prereplication factor AtCDT1.. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102, pp.8216-8221. ⟨10.1073/pnas.0502564102⟩. ⟨hal-00019909⟩