Characterization of cell-fate decision landscapes by estimating transcription factor dynamics

Sara Jiménez (1, 2) , Valérie Schreiber (1, 2) , Reuben Mercier (1, 2) , Gérard Gradwohl (1, 2) , Nacho Molina (1, 2)

1 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
2 UNISTRA - Université de Strasbourg

Highlights d FateCompass is an integrative pipeline to estimate TF activity dynamics d FateCompass learns trajectories using RNA velocity or a differentiation potential d FateCompass reveals known and novel regulators in pancreatic datasets d Lineage tracing validates FateCompass predictions for in vitro b cell differentiation

Domaines: Sciences du Vivant [q-bio]

Sara Jiménez, Valérie Schreiber, Reuben Mercier, Gérard Gradwohl, Nacho Molina. Characterization of cell-fate decision landscapes by estimating transcription factor dynamics. Cell Reports Methods, 2023, pp.100512. ⟨10.1016/j.crmeth.2023.100512⟩. ⟨inserm-04140681⟩