AMPK in skeletal muscle function and metabolism

Rasmus Kjøbsted (1) , Janne Hingst (1) , Joachim Fentz (1) , Marc Foretz (2) , Maria-Nieves Sanz (3, 4) , Christian Pehmøller (5) , Michael Shum (6, 7) , André Marette (8) , Remi Mounier (9) , Jonas T. Treebak (10) , Jørgen F. P. Wojtaszewski (1) , Benoit Viollet (2) , Louise Lantier (11, 12)

1 Department of Nutrition, Exercise and Sports [Copenhagen]
2 IC UM3 (UMR 8104 / U1016) - Institut Cochin
3 Department of Cardiovascular Surgery [Bern, Switzerland]
4 Department of Biomedical Research [Bern, Switzerland]
5 Internal Medicine Research Unit [Cambridge, MA, USA]
6 Axe Cardiologie [Québec, Canada]
7 Institute for Nutrition and Functional Foods [Québec, Canada]
8 INAF - Institute of Nutraceuticals and Functional Foods
9 INMG - Institut NeuroMyoGène
10 CBMR - Novo Nordisk Foundation Center for Basic Metabolic Research
11 Department of Molecular Physiology and Biophysics [Nashville, TN, USA]
12 Mouse Metabolic Phenotyping Center [Nashville, TN, USA]

Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions. AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning anabolic and catabolic pathways. AMPK's role as an energy sensor is particularly critical in tissues displaying highly changeable energy turnover. Due to the drastic changes in energy demand that occur between the resting and exercising state, skeletal muscle is one such tissue. Here, we review the complex regulation of AMPK in skeletal muscle and its consequences on metabolism ( e.g., substrate uptake, oxidation, and storage as well as mitochondrial function of skeletal muscle fibers). We focus on the role of AMPK in skeletal muscle during exercise and in exercise recovery. We also address adaptations to exercise training, including skeletal muscle plasticity, highlighting novel concepts and future perspectives that need to be investigated. Furthermore, we discuss the possible role of AMPK as a therapeutic target as well as different AMPK activators and their potential for future drug development.-Kjøbsted, R., Hingst, J. R., Fentz, J., Foretz, M., Sanz, M.-N., Pehmøller, C., Shum, M., Marette, A., Mounier, R., Treebak, J. T., Wojtaszewski, J. F. P., Viollet, B., Lantier, L. AMPK in skeletal muscle function and metabolism.

Mots clés: diabetes; exercise; glucose uptake; mitochondria; plasticity

Domaines: Endocrinologie et métabolisme

Rasmus Kjøbsted, Janne Hingst, Joachim Fentz, Marc Foretz, Maria-Nieves Sanz, et al.. AMPK in skeletal muscle function and metabolism. FASEB Journal, 2018, 32 (4), pp.1741-1777. ⟨10.1096/fj.201700442R⟩. ⟨inserm-02348651⟩