Skip to Main content Skip to Navigation
Journal articles

Cancer stem cells in Osteosarcoma: Stem cells and osteosarcoma

Abstract : Osteosarcoma is the most common primary bone tumour in children and adolescents and advanced osteosarcoma patients with evidence of metastasis share a poor prognosis. Osteosarcoma frequently gains resistance to standard therapies highlighting the need for improved treatment regimens and identification of novel therapeutic targets. Cancer stem cells (CSC) represent a sub-type of tumour cells attributed to critical steps in cancer including tumour propagation, therapy resistance, recurrence and in some cases metastasis. Recent published work demonstrates evidence of cancer stem cell phenotypes in osteosarcoma with links to drug resistance and tumorigenesis. In this review we will discuss the commonly used isolation techniques for cancer stem cells in osteosarcoma as well as the identified biochemical and molecular markers.
Complete list of metadata

Cited literature [45 references]  Display  Hide  Download
Contributor : Dominique Heymann Connect in order to contact the contributor
Submitted on : Monday, February 13, 2017 - 12:54:08 PM
Last modification on : Friday, August 5, 2022 - 2:47:38 PM
Long-term archiving on: : Sunday, May 14, 2017 - 1:40:16 PM


Brown et al Cancer Letters 201...
Files produced by the author(s)



Hannah K Brown, Marta Tellez-Gabriel, Dominique Heymann. Cancer stem cells in Osteosarcoma: Stem cells and osteosarcoma. Cancer Letters, Elsevier, 2016, 386, pp.189-195. ⟨10.1016/j.canlet.2016.11.019⟩. ⟨inserm-01466078⟩



Record views


Files downloads