Skip to Main content Skip to Navigation
Journal articles

The Bone Niche of Chondrosarcoma: A Sanctuary for Drug Resistance, Tumour Growth and also a Source of New Therapeutic Targets.

Abstract : Chondrosarcomas are malignant cartilage-forming tumours representing around 20% of malignant primary tumours of bone and affect mainly adults in the third to sixth decade of life. Unfortunately, the molecular pathways controlling the genesis and the growth of chondrosarcoma cells are still not fully defined. It is well admitted that the invasion of bone by tumour cells affects the balance between early bone resorption and formation and induces an "inflammatory-like" environment which establishes a dialogue between tumour cells and their environment. The bone tumour microenvironment is then described as a sanctuary that contributes to the drug resistance patterns and may control at least in part the tumour growth. The concept of "niche" defined as a specialized microenvironment that can promote the emergence of tumour stem cells and provide all the required factors for their development recently emerges in the literature. The present paper aims to summarize the main evidence sustaining the existence of a specific bone niche in the pathogenesis of chondrosarcomas.
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00667904
Contributor : D* Heymann <>
Submitted on : Wednesday, February 8, 2012 - 3:56:13 PM
Last modification on : Monday, December 9, 2019 - 2:45:23 PM
Document(s) archivé(s) le : Wednesday, May 9, 2012 - 2:40:59 AM

File

932451.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Emmanuelle David, Frédéric Blanchard, Marie-Françoise Heymann, Gonzague de Pinieux, François Gouin, et al.. The Bone Niche of Chondrosarcoma: A Sanctuary for Drug Resistance, Tumour Growth and also a Source of New Therapeutic Targets.. Sarcoma, Hindawi Publishing Corporation, 2011, 2011, pp.932451. ⟨10.1155/2011/932451⟩. ⟨inserm-00667904⟩

Share

Metrics

Record views

360

Files downloads

583