Model-based Predictions of the Influence of Circadian Clock Genes Knock-Outs on the Cell Cycle

Elisabetta de Maria (1) , Francois Fages (1) , Sylvain Soliman (1)

1 CONTRAINTES - Constraint programming

The existence of links between the cell division cycle and the circadian clock has been recently discovered. In this research report, we perform a small in silico analysis of how mutations on the clock genes composing the mammalian circadian clock affect the phenotype of the cell cycle. For this purpose, we use a coupled model of the mammalian circadian clock and the mammalian cell cycle where the latter one is entrained by the former one via a common protein kinase WEE1. Our in silico experiments exploit the modeling environment BIOCHAM.

Keywords: Cell cycle; circadian clock; model coupling; mutations

Domains: Bioinformatics [q-bio.QM]; Quantitative Methods [q-bio.QM]

Elisabetta de Maria, Francois Fages, Sylvain Soliman. Model-based Predictions of the Influence of Circadian Clock Genes Knock-Outs on the Cell Cycle. [Research Report] 2009. ⟨inria-00424950v1⟩