Maternal obesity reduces apelin level in cord blood without altering the placental apelin/elabela-APJ system.

Sandy Hanssens (1) , Lucie Marousez (2) , Océane Pécheux (3) , Capucine Besengez (4) , Laurent Storme (4) , Philippe Deruelle (5) , Delphine Eberle (6) , Jean Lesage (2)

1 Hôpital Jeanne de Flandre [Lille]
2 LIRIC - Lille Inflammation Research International Center - U 995
3 HUG - Geneva University Hospital
4 METRICS - Evaluation des technologies de santé et des pratiques médicales - ULR 2694
5 CHU Strasbourg - Centre Hospitalier Universitaire [Strasbourg]
6 RNMCD - Récepteurs nucléaires, maladies cardiovasculaires et diabète - U 1011

The APJ receptor and its two endogenous ligands, apelin and elabela, exert key roles in fetoplacental development. In adult, this system is altered by obesity but no data are available during pregnancy. We measured apelin and elabela levels in maternal plasma and cord blood and quantified placental gene expression of apelin, elabela and APJ in obese and non-obese mothers. We found that obesity reduced apelin level in cord blood without affecting maternal and cord blood elabela levels as well as placental gene expression of this system. Our data suggest that obesity alters fetal apelinemia in humans.

Mots clés: Apelin; Elabela; APJ; Maternal obesity; Placenta; Cord blood

Domaines: Sciences du Vivant [q-bio]

Sandy Hanssens, Lucie Marousez, Océane Pécheux, Capucine Besengez, Laurent Storme, et al.. Maternal obesity reduces apelin level in cord blood without altering the placental apelin/elabela-APJ system.. Placenta, 2022, Placenta, 128, pp.112-115. ⟨10.1016/j.placenta.2022.09.011⟩. ⟨hal-04554228⟩