Hypercaloric low-carbohydrate high-fat diet protects against the development of nonalcoholic fatty liver disease in obese mice in contrast to isocaloric Western diet.

Anouk Charlot (1) , Anthony Bringolf (1) , Joris Mallard (1, 2) , Anne-Laure Charles (1) , Nathalie Niederhoffer (3) , Delphine Duteil (4) , Allan Pagano (1) , Bernard Geny (1) , Joffrey Zoll (1)

1 MSP - Mitochondrie, Stress oxydant et Protection musculaire
2 ICANS - Institut de Cancérologie de Strasbourg Europe
3 LPTNC - Laboratoire de pharmacologie et toxicologie neurocardiovasculaire
4 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire

Obesity and metabolic complications, such as type 2 diabetes and nonalcoholic fatty liver disease (NAFLD), are one of the greatest public health challenges of the 21st century. The major role of high sugar and carbohydrate consumption rather than caloric intake in obesity and NAFLD pathophysiology remains a subject of debate. A low-carbohydrate but high-fat diet (LCHFD) has shown promising results in obesity management, but its effects in preventing NAFLD need to be detailed. This study aims to compare the effects of a LCHFD with a high-fat high-sugar obesogenic Western diet (WD) on the progression of obesity, type 2 diabetes, and nonalcoholic fatty liver disease.

Domaines: Alimentation et Nutrition

Anouk Charlot, Anthony Bringolf, Joris Mallard, Anne-Laure Charles, Nathalie Niederhoffer, et al.. Hypercaloric low-carbohydrate high-fat diet protects against the development of nonalcoholic fatty liver disease in obese mice in contrast to isocaloric Western diet.. Frontiers in Nutrition, 2024, 11, ⟨10.3389/fnut.2024.1366883⟩. ⟨hal-04543122⟩