Internal Dynamics and Modular Peripheral Binding in Stimuli‐Responsive 3 : 2 Host:Guest Complexes

Hang Yin , Roselyne Rosas (1) , Stéphane Viel (2, 3, 4) , Michel Giorgi (1) , Valerie Monnier (1) , Laurence Charles (2) , Didier Siri (2) , Didier Gigmes (2) , Youssef Nassar (5) , Floris Chevallier (5) , Christophe Bucher (5) , Ruibing Wang (6) , Anthony Kermagoret (2, 7) , David Bardelang (8)

1 FSCM - Fédération des Sciences Chimiques de Marseille
2 ICR - Institut de Chimie Radicalaire
3 AMU - Aix Marseille Université
4 IUF - Institut universitaire de France
5 LC - Laboratoire de Chimie - UMR5182
6 State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China
7 CINaM - Centre Interdisciplinaire de Nanoscience de Marseille
8 CNRS - Centre National de la Recherche Scientifique

Abstract Now that the chemistry of 1 : 1 host:guest complexes is well‐established, it is surprising to note that higher stoichiometry (oligomeric) complexes, especially those with excess host, remain largely unexplored. Yet, proteins tend to oligomerize, affording new functions for cell machinery. Here, we show that cucurbit[ n ]uril (CB[ n ]) macrocycles combined with symmetric, linear di‐viologens form unusual 3 : 2 host:guest complexes exhibiting remarkable dynamic properties, host self‐sorting, and external ring‐translocation. These results highlight the structural tunability of cucurbit[8]uril (CB[8]) based 3 : 2 host:guest complexes in water and their responsiveness toward several stimuli (chemicals, pH, redox).

Domaines: Chimie

Hang Yin, Roselyne Rosas, Stéphane Viel, Michel Giorgi, Valerie Monnier, et al.. Internal Dynamics and Modular Peripheral Binding in Stimuli‐Responsive 3 : 2 Host:Guest Complexes. Angewandte Chemie International Edition, 2023, ⟨10.1002/anie.202315985⟩. ⟨hal-04371551⟩