Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions

Bálint Mészáros , András Hatos , Nicolas Palopoli , Federica Quaglia , Edoardo Salladini , Kim van Roey , Haribabu Arthanari , Zsuzsanna Dosztányi , Isabella C Felli , Patrick D Fischer , Jeffrey C Hoch , Cy M Jeffries , Sonia Longhi (1) , Emiliano Maiani , Sandra Orchard , Rita Pancsa , Elena Papaleo , Roberta Pierattelli , Damiano Piovesan , Iva Pritisanac , Luiggi Tenorio , Thibault Viennet , Peter Tompa , Wim Vranken , Silvio C E Tosatto , Norman E Davey

1 AFMB - Architecture et fonction des macromolécules biologiques

An unambiguous description of an experiment, and the subsequent biological observation, is vital for accurate data interpretation. Minimum information guidelines define the fundamental complement of data that can support an unambiguous conclusion based on experimental observations. We present the Minimum Information About Disorder Experiments (MIADE) guidelines to define the parameters required for the wider scientific community to understand the findings of an experiment studying the structural properties of intrinsically disordered regions (IDRs). MIADE guidelines provide recommendations for data producers to describe the results of their experiments at source, for curators to annotate experimental data to community resources and for database developers maintaining community resources to disseminate the data. The MIADE guidelines will improve the interpretability of experimental results for data consumers, facilitate direct data submission, simplify data curation, improve data exchange among repositories and standardize the dissemination of the key metadata on an IDR experiment by IDR data sources.

Domaines: Biologie structurale [q-bio.BM]

Bálint Mészáros, András Hatos, Nicolas Palopoli, Federica Quaglia, Edoardo Salladini, et al.. Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions. Nature Methods, In press, ⟨10.1038/s41592-023-01915-x⟩. ⟨hal-04154454⟩