The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion

Thierry Fournier (1) , Laetitia Pavan (1) , Anne Tarrade (1) , Kristina Schoonjans (2) , Johan Auwerx (2) , Cécile Rochette-Egly (2) , Daniele Evain-Brion (2)

1 Développement humain : Croissance et différenciation
2 IGBMC - Institut de génétique et biologie moléculaire et cellulaire

PPAR-gamma/RXR heterodimers play a key regulatory role in murine placental development. We report here that PPAR-gamma and RXR-alpha are highly expressed in cultured primary extravillous cytotrophoblasts (EVCT) isolated from human first-trimester placenta. Using this cell culture model, we showed that PPAR-gamma agonists inhibit EVCT invasion, whereas PPAR-gamma or pan-RXR antagonists promoted EVCT invasion by themselves and abolished PPAR-gamma agonist-mediated effect. Together these data underscore an important function of PPAR/RXR heterodimers in the modulation of trophoblast invasion.

Domaines: Biochimie, Biologie Moléculaire

Thierry Fournier, Laetitia Pavan, Anne Tarrade, Kristina Schoonjans, Johan Auwerx, et al.. The role of PPAR-gamma/RXR-alpha heterodimers in the regulation of human trophoblast invasion. Annals of the New York Academy of Sciences, 2002, 973, pp.26-30. ⟨10.1111/j.1749-6632.2002.tb04601.x⟩. ⟨hal-04145096⟩