Expression of the helix-loop-helix gene id3 in the zebrafish embryo

Thomas Dickmeis (1) , Sepand Rastegar (1) , Chen Sok Lam (2) , Pia Aanstad (3) , Matthew Clark (3) , Nadine Fischer (1) , Frédéric Rosa (4) , Vladimir Korzh (2) , Uwe Strähle (1)

1 IGBMC - Institut de génétique et biologie moléculaire et cellulaire
2 NUS - National University of Singapore
3 MPIMG - Max-Planck-Institut für Molekulare Genetik
4 Biologie Moléculaire du Développement

Proteins of the Extramacrochaetae and Id subfamily of Helix-Loop-Helix (HLH) proteins are negative regulators of bHLH transcription factors. We cloned a cDNA from zebrafish which encodes a member of the id3 subfamily. High levels of transcripts accumulated in the germ ring and in the embryonic shield. Towards the end of gastrulation, Id3 was highly expressed in the anterior prechordal plate and hypoblast. At later stages, id3 expression was turned on and off in a large variety of tissues within short periods of time. These include the lateral mesoderm, the cornea, the lens, the brain, the neural crest, the retina and the fins.

Domaines: Sciences du Vivant [q-bio]

Thomas Dickmeis, Sepand Rastegar, Chen Sok Lam, Pia Aanstad, Matthew Clark, et al.. Expression of the helix-loop-helix gene id3 in the zebrafish embryo. Mechanisms of Development, 2002, 113 (1), pp.99-102. ⟨10.1016/s0925-4773(02)00006-0⟩. ⟨hal-04144125⟩