SRC-1 and TIF2 control energy balance between white and brown adipose tissues

Frédéric Picard (1) , Martine Géhin (1) , Jean-Sébastien Annicotte (1) , Stéphane Rocchi (1) , Marie-France Champy (2) , Bert W. O'Malley (3) , Pierre Chambon (1, 2) , Johan Auwerx (1, 2)

1 IGBMC - Institut de génétique et biologie moléculaire et cellulaire
2 ICS - Institut Clinique de la Souris
3 BCM - Baylor College of Medicine

We have explored the effects of two members of the p160 coregulator family on energy homeostasis. TIF2-/- mice are protected against obesity and display enhanced adaptive thermogenesis, whereas SRC-1-/- mice are prone to obesity due to reduced energy expenditure. In white adipose tissue, lack of TIF2 decreases PPARgamma activity and reduces fat accumulation, whereas in brown adipose tissue it facilitates the interaction between SRC-1 and PGC-1alpha, which induces PGC-1alpha's thermogenic activity. Interestingly, a high-fat diet increases the TIF2/SRC-1 expression ratio, which may contribute to weight gain. These results reveal that the relative level of TIF2/SRC-1 can modulate energy metabolism.

Domaines: Biologie cellulaire

Frédéric Picard, Martine Géhin, Jean-Sébastien Annicotte, Stéphane Rocchi, Marie-France Champy, et al.. SRC-1 and TIF2 control energy balance between white and brown adipose tissues. Cell, 2002, 111 (7), pp.931-941. ⟨10.1016/s0092-8674(02)01169-8⟩. ⟨hal-04143721⟩