Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I

Kristina Schoonjans (1) , Jean‐sebastien Annicotte (1) , Thierry Huby (2, 3) , Oronza Botrugno (1) , Elisabeth Fayard (1) , Yukihiko Ueda , John Chapman (2, 3) , Johan Auwerx (1)

1 IGBMC - Institut de génétique et biologie moléculaire et cellulaire
2 CHU Pitié-Salpêtrière [AP-HP]
3 Dyslipoproteinémies et athérosclerose : Génétique, métabolisme et thérapeutique

The scavenger receptor class B type I (SR-BI), which mediates selective cellular cholesterol uptake from high-density lipoproteins (HDLs), plays a key role in reverse cholesterol transport. The orphan nuclear receptor liver receptor homolog 1 (LRH-1) and SR-BI are co-expressed in liver and ovary, suggesting that LRH-1 might control the expression of SR-BI in these tissues. LRH-1 induces human and mouse SR-BI promoter activity by binding to an LRH-1 response element in the promoter. Retroviral expression of LRH-1 robustly induces SR-BI, an effect associated with histone H3 acetylation on the SR-BI promoter. The decrease in SR-BI mRNA levels in livers of LRH-1(+/-) animals provides in vivo evidence that LRH-1 regulates SR-BI expression. Our data demonstrate that SR-BI is an LRH-1 target gene and underscore the pivotal role of LRH-1 in reverse cholesterol transport.

Domaines: Biochimie, Biologie Moléculaire

Kristina Schoonjans, Jean‐sebastien Annicotte, Thierry Huby, Oronza Botrugno, Elisabeth Fayard, et al.. Liver receptor homolog 1 controls the expression of the scavenger receptor class B type I. EMBO Reports, 2002, 3 (12), pp.1181-1187. ⟨10.1093/embo-reports/kvf238⟩. ⟨hal-04142471⟩