Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma

Frédéric Lemaire (1) , Regine Millon (2) , Danièle Muller (2) , Yannick Rabouel (2) , Laurent Bracco (3) , Joseph Abecassis (2) , Bohdan Wasylyk (1)

1 IGBMC - Institut de génétique et biologie moléculaire et cellulaire
2 Progression tumorale et microenvironnement. Approches translationnelles et épidémiologie
3 ExonHit Therapeutics SA

We report that homeodomain-only protein (HOP) is expressed in the suprabasal layer of normal upper aerodigestive tract epithelium and expression strongly decreases in hypopharyngeal carcinoma. Interestingly, HOP has very recently been shown to be a tumour suppressor involved in differentiation, suggesting that HOP may have a similar role in head and neck squamous cell carcinoma (HNSSC).

Domaines: Cancer

Frédéric Lemaire, Regine Millon, Danièle Muller, Yannick Rabouel, Laurent Bracco, et al.. Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma. British Journal of Cancer, 2004, 91 (2), pp.258-261. ⟨10.1038/sj.bjc.6601952⟩. ⟨hal-04130445⟩