Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development

Regis Masson (1) , Catherine H. Régnier (1) , Marie-Pierre Chenard (2) , Corinne Wendling (1) , Marie-Genevieve Mattei (3) , Catherine Tomasetto (1) , Marie-Christine Rio (1)

1 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire
2 Hôpital de Hautepierre [Strasbourg]
3 TIMONE - Hôpital de la Timone [CHU - APHM]

This is the first in situ hybridization analysis of expression of a tumor necrosis factor (TNF) receptor associated factor (TRAF) during development. TRAF4 is observed throughout mouse embryogenesis, most notably during ontogenesis of the central (CNS) and peripheral (PNS) nervous system, and of nervous tissues of sensory organs. TRAF4 is preferentially expressed by post-mitotic undifferentiated neurons. Interestingly, TRAF4 remains expressed in the adult hippocampus and olfactory bulb, known to contain multipotential cells responsible for neoneurogenesis.

Domaines: Biochimie, Biologie Moléculaire

Regis Masson, Catherine H. Régnier, Marie-Pierre Chenard, Corinne Wendling, Marie-Genevieve Mattei, et al.. Tumor necrosis factor receptor associated factor 4 (TRAF4) expression pattern during mouse development. Mechanisms of Development, 1998, 71 (1-2), pp.187-191. ⟨10.1016/s0925-4773(97)00192-5⟩. ⟨hal-04057117⟩