A genetic dissection of the retinoid signalling pathway in the mouse

Manuel Mark (1, 2) , Norbert Ghyselinck (1, 2) , Olivia Wendling (1, 2) , Valérie Dupé , Bénédicte Mascrez , Philippe Kastner (2, 1) , Pierre Chambon (1, 2)

1 IGBMC - Institut de génétique et biologie moléculaire et cellulaire
2 IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire

To determine the functions of retinoic acid receptors RAR and RXR, we have systematically knocked-out their genes by homologous recombination in the embryonic stem cells and generated null-mutant mice. This approach has allowed us to perform a genetic dissection of the retinoic acid signalling pathway.

Domaines: Biochimie, Biologie Moléculaire

Manuel Mark, Norbert Ghyselinck, Olivia Wendling, Valérie Dupé, Bénédicte Mascrez, et al.. A genetic dissection of the retinoid signalling pathway in the mouse. Proceedings of the Nutrition Society, 1999, 58 (3), pp.609-613. ⟨10.1017/s0029665199000798⟩. ⟨hal-03991565⟩