Structure-based and knowledge-informed design of B-Raf inhibitors devoid of deleterious PXR binding

Melanie Schneider , Vanessa Delfosse (1) , Muriel Gelin (1) , Marina Grimaldi (2) , Meritxell Granell , Laurène Heriaud , Jean-Luc Pons , Martin Cohen Gonsaud (1) , Patrick Balaguer (3) , William Bourguet (1) , Gilles Labesse (1)

1 CBS - Centre de Biologie Structurale [Montpellier]
2 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier
3 IRCM - U1194 Inserm - UM - Institut de Recherche en Cancérologie de Montpellier

Domaines: Biochimie [q-bio.BM]; Biologie moléculaire; Biophysique; Biologie structurale [q-bio.BM]

Melanie Schneider, Vanessa Delfosse, Muriel Gelin, Marina Grimaldi, Meritxell Granell, et al.. Structure-based and knowledge-informed design of B-Raf inhibitors devoid of deleterious PXR binding. Journal of Medicinal Chemistry, 2022, 65 (2), pp.1552-1566. ⟨10.1021/acs.jmedchem.1c01354⟩. ⟨hal-03857821⟩